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TAP 导读: Brain clearance is reduced during sleep and anesthesia

该小鼠研究在所测状态下观察到相近的扩散系数，却在恢复睡眠及所用麻醉条件下估计到较低的示踪剂清除。结果提示需要把分子扩散、脑内分布和清除区分开，并对照具体实验方法理解睡眠研究。

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01 / RECORD

作品信息

TAP ID
TAP-RDN-0063
作品类型
研究导读
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v1.0 · 中文 ↗
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原始出版物

Brain clearance is reduced during sleep and anesthesia

Miao A · Luo T · Hsieh B · Edge CJ · Gridley M · Wong RTC · Constandinou TG · Wisden W · Franks NP
Nature Neuroscience · 2024

DOI: 10.1038/s41593-024-01638-y ↗

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项目信息隐私政策项目信息联系我们评估工具TAP 负荷与恢复评估方法负荷与恢复评估：方法与开发探索频道关于人体适应的科学问题探索频道测量与解释阅读指南 · 精选 35 篇负荷与恢复：六条研究线索阅读指南 · 精选 5 篇适应负荷阅读指南 · 精选 5 篇恢复科学阅读指南 · 精选 5 篇储备与复原力阅读指南 · 精选 5 篇测量与解释基础概念负荷Load基础概念动态适应Allostasis基础概念恢复Recovery基础概念适应负荷Allostatic Load基础概念生理储备Physiological Reserve基础概念复原力Resilience科学专题适应负荷：适应的隐性成本科学专题恢复，不只是休息科学专题什么是复原力营养？科学专题适应模型：不同框架分别解释什么？科学专题TAP 人体动态适应框架科学专题HRV 下降了：正常波动，还是恢复状态发生了变化？科学专题HRV 能告诉我们多少关于恢复的信息？科学专题为什么下班了，身体还没有“下班”？科学专题吃得不够，会影响恢复吗？科学专题周末补觉，能补回一周的睡眠不足吗？科学专题怎样证明一种营养干预支持恢复？科学专题恢复一定意味着回到原来的基线吗？科学专题恢复与复原力是一回事吗？科学专题感觉好一些，为什么不一定代表已经恢复？科学专题手表上的恢复分数，到底在告诉你什么？科学专题生理储备与复原力是什么关系？方法与项目证据分级与评价方法方法与项目编辑与科学标准方法与项目关于项目研究文献 · 1993Stress and the individual. Mechanisms leading to disease研究文献 · 1998Protective and damaging effects of stress mediators研究文献 · 2001Frailty in older adults: evidence for a phenotype研究文献 · 2003The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation研究文献 · 2004Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research研究文献 · 2006The perseverative cognition hypothesis: a review of worry, prolonged stress-related physiological activation, and health研究文献 · 2007The Recovery Experience Questionnaire: development and validation of a measure for assessing recuperation and unwinding from work研究文献 · 2009The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress研究文献 · 2010Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery研究文献 · 2010Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidence研究文献 · 2010Allostatic load biomarkers of chronic stress and impact on health and cognition研究文献 · 2011Stress- and Allostasis-Induced Brain Plasticity研究文献 · 2012Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data研究文献 · 2012Allostasis: a model of predictive regulation研究文献 · 2012A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health研究文献 · 2012Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial研究文献 · 2013Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis研究文献 · 2013The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance研究文献 · 2013Effects of recovery sleep after one work week of mild sleep restriction on interleukin-6 and cortisol secretion and daytime sleepiness and performance研究文献 · 2013Sleep drives metabolite clearance from the adult brain研究文献 · 2014Monitoring training status with HR measures: do all roads lead to Rome?研究文献 · 2014Clarifying the roles of homeostasis and allostasis in physiological regulation研究文献 · 2014Resilience definitions, theory, and challenges: interdisciplinary perspectives研究文献 · 2015Recovery from job stress: The stressor-detachment model as an integrative framework研究文献 · 2016Physiological concomitants of perseverative cognition: A systematic review and meta-analysis研究文献 · 2016Successfully leaving work at work: The self-regulatory underpinnings of psychological detachment研究文献 · 2016Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct研究文献 · 2017Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis研究文献 · 2017Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans研究文献 · 2017Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research - Recommendations for Experiment Planning, Data Analysis, and Data Reporting研究文献 · 2017The impact of reduced worktime on sleep and perceived stress - a group randomized intervention study using diary data研究文献 · 2017A Meta-Analysis on Antecedents and Outcomes of Detachment from Work研究文献 · 2017Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge研究文献 · 2018Recovery and Performance in Sport: Consensus Statement研究文献 · 2018Quantifying resilience of humans and other animals研究文献 · 2019Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep研究文献 · 2019Resilience in Clinical Care: Getting a Grip on the Recovery Potential of Older Adults研究文献 · 2019Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial研究文献 · 2020Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial研究文献 · 2020Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance研究文献 · 2021Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit研究文献 · 2021Leaving Work at Work: A Meta-Analysis on Employee Recovery From Work研究文献 · 2022"Give me a break!" 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