Stress and the individual. Mechanisms leading to disease
Bruce S. McEwen · Eliot Stellar
Archives of Internal Medicine · 1993
What the research tells us
Introduces allostatic load as a way to understand the physiological costs that may accompany prolonged challenges.
Scope & interpretation
This conceptual review connects human and animal research to explain cumulative costs of adaptation. Specific intervention effects require corresponding human studies.
Study at a glance
- POPULATION & SAMPLE
- Synthesis of human and animal research; no single trial sample
- EXPOSURE / INTERVENTION / SUBJECT
- Repeated/chronic environmental demands; conceptual synthesis
- OUTCOMES
- Physiological adaptation and disease mechanisms
- TIME FRAME
- No single observation period
Cited on this site
Allostasis
Allostatic Load
Allostatic Load: The Hidden Cost of Adaptation
Models of Adaptation: What Different Frameworks Explain
TAP Human Adaptation Framework
Editorial & review record
Record for v0.2 · Updated
Editorial responsibility: TAP Editorial Team
Scientific review
Not yet scientifically reviewed
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing. Scientific review is recorded separately on this page.
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How responsibilities and review are recorded ↗Scope of this reading note
Bibliographic details verified; full-text verification is incomplete.
- Funding & competing interests
- Funding and competing-interest details have not been verified against the full text. Consult the original publication’s declarations.
Project support
Founded and supported by Resilio.
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