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Research library / 1993 / Conceptual review

Stress and the individual. Mechanisms leading to disease

Bruce S. McEwen · Eliot Stellar
Archives of Internal Medicine · 1993

What the research tells us

Introduces allostatic load as a way to understand the physiological costs that may accompany prolonged challenges.

What to keep in mind

This conceptual review integrates human and animal research. It does not directly establish that a particular intervention or product is effective.

Study details

Source-linked reading note. Bibliographic details checked; full-text extraction and scientific review remain incomplete.

POPULATION & SAMPLE
Synthesis of human and animal research; no single trial sample
EXPOSURE / INTERVENTION / SUBJECT
Repeated/chronic environmental demands; conceptual synthesis
OUTCOMES
Physiological adaptation and disease mechanisms
TIME FRAME
No single observation period
STUDY FUNDING
Not yet verified against the full text.
STUDY CONFLICTS OF INTEREST
Not yet verified against the full text.

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Editorial & review record
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FoundationsLoadFoundationsAllostasisFoundationsAllostatic LoadFoundationsRecoveryFoundationsPhysiological ReserveFoundationsResilienceFeaturesAllostatic Load: The Hidden Cost of AdaptationFeaturesRecovery Is Not RestMethods & projectEvidence grading & methodsMethods & projectEditorial & scientific standardsMethods & projectAbout the projectResearch · 1993Stress and the individual. Mechanisms leading to diseaseResearch · 1998Protective and damaging effects of stress mediatorsResearch · 2003The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivationResearch · 2010Greater cardiovascular responses to laboratory mental stress are associated with poor subsequent cardiovascular risk status: a meta-analysis of prospective evidenceResearch · 2011Stress- and Allostasis-Induced Brain PlasticityResearch · 2012Allostasis: a model of predictive regulationResearch · 2015Recovery from job stress: The stressor-detachment model as an integrative frameworkResearch · 2016Physical Resilience in Older Adults: Systematic Review and Development of an Emerging ConstructResearch · 2017A Meta-Analysis on Antecedents and Outcomes of Detachment from WorkResearch · 2018Recovery and Performance in Sport: Consensus StatementResearch · 2022Allostatic Load Measurement: A Systematic Review of Reviews, Database Inventory, and Considerations for Neighborhood Research