Allostatic (over) load measurement: Workflow and repository
Beese S · Cross J · Rice D · DeJong TL
PLOS One · 2026
What the research tells us
The paper makes allostatic-load data cleaning, marker selection and scoring more reproducible, applying a shared workflow separately to All of Us, HRS and NHANES. Its main contribution is traceable measurement choices rather than validation of a new clinical score.
Scope & interpretation
Within-sample quantiles depend on population and measurement. Table 9 lists CRP cutoffs of 14.20, 4.29 and 4.14, with a coefficient of variation of 0.7638; their relationship to the text's heterogeneity summary needs clarification of units and scope. This unresolved discrepancy is not a formal correction and does not establish interchangeable thresholds.
Study at a glance
- POPULATION & SAMPLE
- Three databases analysed separately; the All of Us workflow included 37,866 people. Individual records were not pooled across databases.
- EXPOSURE / INTERVENTION / SUBJECT
- Cleaning and quantile-based risk scoring of five markers, using historical NHANES extremes to inform plausibility ranges and discussing clinical-cutoff sensitivity analyses.
- OUTCOMES
- Workflow, retained samples and biomarker thresholds; no single clinical-validation endpoint.
- TIME FRAME
- Observation periods differ by database; the study addresses measurement rather than recovery after an intervention.
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Scientific review
Not yet scientifically reviewed
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing. Scientific review is recorded separately on this page.
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How responsibilities and review are recorded ↗Scope of this reading note
Full-text methods, cleaning/scoring, Tables 3 and 9 and limitations. Code, complex-survey weighting and all supplements have not been independently checked.
- Study funding
- The authors report no specific funding for this work.
- Competing interests
- The authors declare no competing interests.
Project support
Founded and supported by Resilio.
Revision history
- · v1.0
Added the cross-database workflow and its unresolved CRP-threshold discrepancy.