Resilience phenotypes derived from an active inference account of allostasis
Laura A. Harrison · Antonio J. Gracias · Karl J. Friston · J. Galen Buckwalter
Frontiers in Behavioral Neuroscience · 2025
What the research tells us
Proposes an active-inference account of allostasis and four resilience phenotypes. Environment, prediction and actions that shape the environment are central to the explanation.
Scope & interpretation
The four phenotypes are theoretical categories for empirical testing. The paper contributes models and research questions; clinical classification would require further evaluation.
Study at a glance
- POPULATION & SAMPLE
- Theoretical synthesis; no new validation cohort for the four phenotypes.
- EXPOSURE / INTERVENTION / SUBJECT
- Enactive allostasis and strategies for engaging with a changing environment.
- OUTCOMES
- Proposed fragile, durable, resilient and pro-entropic phenotypes.
- TIME FRAME
- No single experimental or follow-up period.
Cited on this site
Models of Adaptation: What Different Frameworks Explain
TAP Human Adaptation Framework
Editorial & review record
Record for v0.2 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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How responsibilities and review are recorded ↗Scope of this reading note
Publisher full text and PMC full-text XML, including the article type, proposed phenotypes and funding/conflict declarations.
- Study funding
- The authors report no financial support for the research or publication.
- Competing interests
- The authors report no commercial or financial conflicts and disclose Frontiers editorial-board membership at submission.
Project support
Founded and supported by Resilio.
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