Allostatic Load and Mortality: A Systematic Review and Meta-Analysis
Haley W. Parker · Alyssa M. Abreu · Mary C. Sullivan · Maya K. Vadiveloo
American Journal of Preventive Medicine · 2022
What the research tells us
Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies.
Scope & interpretation
Heterogeneity was high for most pooled estimates, with I² above 90%. Results describe associations with mortality; intervention benefits and individual risk prediction require separate evaluation.
Study at a glance
- POPULATION & SAMPLE
- Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.
- EXPOSURE / INTERVENTION / SUBJECT
- Higher versus lower allostatic load, as defined separately by each study.
- OUTCOMES
- All-cause and cardiovascular mortality; these outcomes were synthesized separately.
- TIME FRAME
- Database searches in May 2021; eligible studies published from 2001 to 2020.
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Editorial & review record
Record for v0.2 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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How responsibilities and review are recorded ↗Scope of this reading note
Selected research interpretation based on the original abstract and bibliographic record.
- Funding & competing interests
- Funding and competing-interest details have not been verified against the full text. Consult the original publication’s declarations.
Project support
Founded and supported by Resilio.
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