Acute sleep rebound following sleep restriction is associated with reduced mortality risk
Xiaoyu Li · Manrui Zhang · Zhenyu Li · Shengkui Zhang · Suzanne M. Bertisch · Tianyi Huang · Martin K. Rutter · Susan Redline
Nature Communications · 2026
What the research tells us
Mortality associations differed across restriction/rebound patterns; rebound groups were not significantly different from regular sleep.
Scope & interpretation
Observational; rebound is not specifically weekend sleep. Non-significance does not establish equivalence or causation.
Study at a glance
- POPULATION & SAMPLE
- 85,618 UK Biobank participants; replication in 4,586 NHANES participants.
- EXPOSURE / INTERVENTION / SUBJECT
- Accelerometer-derived restriction and subsequent rebound.
- OUTCOMES
- Mortality associations.
- TIME FRAME
- Median UK Biobank follow-up: 8.0 years.
Cited on this site
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Scientific review
Not yet scientifically reviewed
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing. Scientific review is recorded separately on this page.
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How responsibilities and review are recorded ↗Scope of this reading note
Publisher full text: methods, results and declarations.
- Study funding
- No specific study funding statement was identified in the consulted main text.
- Competing interests
- M. K. Rutter: Eli Lilly consulting and modest GSK holdings, reported as unrelated. S. Redline: Eli Lilly consulting, Sleep Health editorship, unpaid National Sleep Foundation and Alliance of Sleep Apnea Partners board roles. Others declared no competing interests.
Project support
Founded and supported by Resilio.
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