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The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation

Hans P. A. Van Dongen · Greg Maislin · Janet M. Mullington · David F. Dinges
Sleep · 2003

What the research tells us

Repeated sleep restriction produced cumulative cognitive performance deficits that subjective sleepiness did not fully track.

What to keep in mind

Laboratory sleep restriction does not define everyone’s recovery timeline or a universal recovery debt.

Study details

Source-linked reading note. Bibliographic details checked; full-text extraction and scientific review remain incomplete.

POPULATION & SAMPLE
48 healthy adults aged 21–38; experiments included 14 nights of restricted time in bed
EXPOSURE / INTERVENTION / SUBJECT
4, 6 or 8 hours in bed per night; a separate total-deprivation experiment
OUTCOMES
Cognitive performance, subjective sleepiness and sleep physiology
TIME FRAME
14 nights of restriction or 3 nights without sleep; 3 baseline and 3 recovery days in each experiment
STUDY FUNDING
Not yet verified against the full text.
STUDY CONFLICTS OF INTEREST
Not yet verified against the full text.

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