The Reactive Scope Model — A new model integrating homeostasis, allostasis, and stress
L. Michael Romero · Molly J. Dickens · Nicole E. Cyr
Hormones and Behavior · 2009
What the research tells us
Proposes four ranges of physiological mediators: predictable regulation, responses to unexpected demands, overload and failure. The authors use changing boundaries to describe how history and context may alter an individual’s reactive scope.
Scope & interpretation
The model proposes changing response ranges and provides a structure for conceptual and comparative research. Translating ranges into human measurement thresholds requires system- and population-specific validation.
Study at a glance
- POPULATION & SAMPLE
- No new cohort or intervention trial is reported in the abstract.
- EXPOSURE / INTERVENTION / SUBJECT
- Predictable and unpredictable demands; mediator levels and changing response ranges.
- OUTCOMES
- A graphical model of regulation and overload, not a clinical effect estimate.
- TIME FRAME
- Multiple timescales; no single follow-up period.
Cited on this site
Models of Adaptation: What Different Frameworks Explain
TAP Human Adaptation Framework
Editorial & review record
Record for v0.2 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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How responsibilities and review are recorded ↗Scope of this reading note
PubMed/Europe PMC abstract and bibliographic metadata, focused on the proposed regulatory model. Cross-species empirical validation is outside this note’s scope.
- Funding & competing interests
- The consulted abstract includes no funding or competing-interest statement. Consult the full publication for these disclosures.
Project support
Founded and supported by Resilio.
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