TAP reading note: Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans
Combining macaque tracing literature with human resting-state connectivity, the study proposes a large-scale system supporting allostasis and interoception. In a separate human sample, connectivity was associated with correspondence between subjective arousal and skin-conductance responses to images, providing correlational support for the proposed network.
Updated 2026-10-29 · Archived
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What the study found
Combining macaque tracing literature with human resting-state connectivity, the study proposes a large-scale system supporting allostasis and interoception. In a separate human sample, connectivity was associated with correspondence between subjective arousal and skin-conductance responses to images, providing correlational support for the proposed network.
Scope & limitations
Discovery sample of 280 and replication sample of 270; 41 of 66 participants in the validation study had usable imaging and skin-conductance data.
Functional connectivity does not establish direct anatomical connections or causal regulation. Vascular effects, brainstem resolution, cross-species mapping and sample selection constrain interpretation. Energy expenditure, allostatic load and individual recovery scores were not directly validated.
Population & sample
Discovery sample of 280 and replication sample of 270; 41 of 66 participants in the validation study had usable imaging and skin-conductance data.
Exposure or intervention
Resting-state fMRI and an image-evoked arousal task, interpreted alongside cross-species anatomical literature.
Outcomes
Connectivity and correspondence between subjective and physiological arousal; the reported association test had P=.003.
Time frame
Imaging and laboratory-task measurements, without long-term clinical follow-up.
Research funding
NIA R01 AG030311; US Army Research Institute W5J9CQ-11-C-0046 and W5J9CQ-12-C-0049; NIMH F32MH096533 and K01MH096175-01; NCI UG1 CA189961 and R25 CA102618; additional Oklahoma Tobacco Research Center and Fonds de recherche santé Québec fellowship support.
Research conflicts of interest
The authors declare no competing interests and report no funder involvement in study design or the publication decision.
Reading scope
Full-text discovery, replication, validation, limitations and disclosures. Supplementary discussion and sensitivity to sample exclusions remain to be examined.
References
Publication record
TAP-RDN-0049 · v1.0 · English
Author: TAP Editorial Team ·
The Allostasis Project is founded and supported by Resilio.
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Scientific review
Not yet scientifically reviewed
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing. Scientific review is recorded separately on this page.
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Record integrity & available editions
SHA-256: 2b923a381aed6188cb89b4e74152a8ea339014e1af3ed0ee6adeb6ee44c1bdda
Captured: 2026-10-29T10:31:13.625Z
- v1.0 · 2026-10-29