TAP reading note: Towards a consensus definition of allostatic load: a multi-cohort, multi-system, multi-biomarker individual participant data (IPD) meta-analysis
Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported.
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What the study found
Across 13 cohorts, the authors compared biomarker associations with function and self-rated health. A five-marker index performed as well as or better than more elaborate combinations for mortality prediction in the analyses reported.
Scope & limitations
Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems.
The findings inform biomarker harmonization in the cohorts and outcomes studied. Extension to other populations, diagnosis or intervention evaluation requires assessment of performance and applicability.
Population & sample
Individual-participant-data analysis of 67,126 people aged 40–111 years; 40 candidate biomarkers across 12 physiological systems.
Exposure or intervention
Alternative biomarker combinations used to operationalize allostatic load.
Outcomes
Grip strength, walking speed and self-rated health; mortality used as a separate outcome.
Time frame
Multiple cohorts with differing observation periods; published in 2023.
Research funding
Not yet checked against the full publication.
Research conflicts of interest
Not yet checked against the full publication.
Reading scope
Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal.
References
Publication record
TAP-RDN-0014 · v0.2 · English
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Record for v0.2 · Updated
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Editorial note
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