TAP reading note: Allostatic Load and Mortality: A Systematic Review and Meta-Analysis
Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies.
Updated 2026-10-27 · Archived
The scientific content and references belong to this edition. The complete captured record is available to download below; later corrections appear in subsequent editions. Website design and interactive software are not archived here.
What the study found
Higher allostatic load was associated with higher all-cause and cardiovascular mortality in pooled observational evidence. The size of the association varied substantially between studies.
Scope & limitations
Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.
Heterogeneity was high for most pooled estimates, with I² above 90%. Results describe associations with mortality; intervention benefits and individual risk prediction require separate evaluation.
Population & sample
Systematic review of 17 eligible studies. Main pooled estimates used 10 studies for all-cause mortality and six for cardiovascular mortality.
Exposure or intervention
Higher versus lower allostatic load, as defined separately by each study.
Outcomes
All-cause and cardiovascular mortality; these outcomes were synthesized separately.
Time frame
Database searches in May 2021; eligible studies published from 2001 to 2020.
Research funding
Not yet checked against the full publication.
Research conflicts of interest
Not yet checked against the full publication.
Reading scope
Based on the original publication’s abstract and bibliographic record. This is a selected reading note, not a systematic appraisal.
References
Publication record
TAP-RDN-0015 · v0.2 · English
The Allostasis Project is founded and supported by Resilio.
Record for v0.2 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
Download detailed editorial record (JSON) ↓
How responsibilities and review are recorded ↗© The Allostasis Project. All rights reserved. Reproduction or adaptation requires separate permission, subject to applicable legal exceptions.