TAP reading note: Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep
In this short laboratory protocol, two unrestricted weekend nights followed by renewed restriction did not prevent the observed metabolic dysregulation. Whole-body insulin sensitivity fell by approximately 13% and 27% from each group's own baseline in continuous restriction and weekend recovery respectively. Those within-group percentages do not establish a significant between-group difference.
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What the study found
In this short laboratory protocol, two unrestricted weekend nights followed by renewed restriction did not prevent the observed metabolic dysregulation. Whole-body insulin sensitivity fell by approximately 13% and 27% from each group's own baseline in continuous restriction and weekend recovery respectively. Those within-group percentages do not establish a significant between-group difference.
Scope & limitations
36 young, normal-weight healthy adults, 18 women and 18 men: eight controls, 14 continuous-restriction and 14 weekend-recovery participants.
The sample and duration were limited, while sleep, intake, weight and circadian timing changed together. The weight-adjusted weekend-recovery analysis had P=.054. Differences between adjusted and unadjusted results matter; the experiment does not establish that every form of catch-up sleep is without value.
Population & sample
36 young, normal-weight healthy adults, 18 women and 18 men: eight controls, 14 continuous-restriction and 14 weekend-recovery participants.
Exposure or intervention
Nine-hour nightly sleep opportunity for controls, five hours for continuous restriction, or restriction followed by two unrestricted nights and renewed restriction.
Outcomes
Clamp-measured insulin sensitivity, energy intake, weight and circadian measures.
Time frame
A controlled restriction–weekend recovery–restriction cycle, without long-term free-living follow-up.
Research funding
NIH HL109706, DK111161, TR001082, DK048520 and Sleep Research Society Foundation 011-JP-16.
Research conflicts of interest
K. P. Wright disclosed NIH advisory-board membership/personal fees, Torvec scientific advice/personal fees, fees from Circadian Therapeutics and Kellogg, and outside-study support from NIH, the Office of Naval Research, PAC-12 and Somalogic. Other authors reported nothing to disclose.
Reading scope
Full-text results, STAR Methods randomization/clamp measurements, discussion and limitations. All between-group and adjusted models have not been independently reproduced.
References
Publication record
TAP-RDN-0025 · v0.3 · English
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Record for v0.3 · Updated
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