Seven robust and easy to obtain biomarkers to measure acute stress
Hogenelst K, Özsezen S, Kleemann R, Verschuren L, Stuldreher I, Bottenheft C, van Erp J, Brouwer AM
Brain, behavior, & immunity - health · 2024
What the research tells us
Negative affect, heart rate, electrodermal responses and four cytokine measures changed in the same direction on both days. Cortisol AUCi was not significantly different from zero. The results concern sensitivity to acute stress, not whole-system recovery.
Scope & interpretation
Group-level repeatability does not establish stable individual ranking: only plasma IL-22 showed a significant across-day rank correlation among the seven selected markers. No universal recovery panel was validated.
Study at a glance
- POPULATION & SAMPLE
- 101 participants on day one; 48 tested with another social stressor on day two.
- EXPOSURE / INTERVENTION / SUBJECT
- Standardized acute social stress on two consecutive days.
- OUTCOMES
- Affect, autonomic signals, cortisol and plasma/salivary cytokines.
- TIME FRAME
- Two-day protocol; repeated pre/post-stressor measurements.
Cited on this site
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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How responsibilities and review are recorded ↗Scope of this reading note
University-hosted full text: methods, Tables 1–2, results on repeated responses, discussion and declarations. Individual data were not reanalysed.
- Study funding
- TNO Early Research Program Body–Brain Interaction. Acknowledgements also credit Quanterix staff for help developing salivary cytokine assays.
- Competing interests
- The authors declare no competing interests.
Project support
Founded and supported by Resilio.
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