Multi-systemic evaluation of biological and emotional responses to the Trier Social Stress Test: A meta-analysis and systematic review
Man ISC, Shao R, Hou WK, Xin Li S, Liu FY, Lee M, Wing YK, Yau SY, Lee TMC
Frontiers in neuroendocrinology · 2023
What the research tells us
Cortisol and negative mood were the most sensitive markers in the selected multi-system TSST literature. Sensitivity of other systems was less consistent or based on fewer studies. The result depends on the measure and time contrast.
Scope & interpretation
Limited studies for several markers, selected healthy samples and differing time contrasts. Sensitive response markers are not universal personal recovery thresholds.
Study at a glance
- POPULATION & SAMPLE
- 61 studies in the review; 58 in meta-analyses, with 2,459 healthy participants aged 18–65.
- EXPOSURE / INTERVENTION / SUBJECT
- TSST exposure with biological and emotional measurements.
- OUTCOMES
- Endocrine, physiological, inflammatory and emotional changes; separate time contrasts.
- TIME FRAME
- Included publications spanned 2005–2020; review in the 2023 journal issue.
Cited on this site
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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How responsibilities and review are recorded ↗Scope of this reading note
University-repository full text: eligibility, study counts, outcome definitions, results and declarations. Supplementary analyses were not independently reproduced.
- Study funding
- Hong Kong Research Grants Council Collaborative Research Fund C7079-19GF (T. Lee); Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence Open Fund 2019007 (R. Shao).
- Competing interests
- The authors declare no competing interests.
Project support
Founded and supported by Resilio.
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