How the Acute Psychosocial Stress Response Ends: A Post-Stressor Transition Model of Glucocorticoid Feedback, Vagal Re-Engagement, and Frontolimbic Context Updating
Liu C, Zheng R, Wu Y, Zhang M
International journal of molecular sciences · 2026
What the research tells us
Proposes a post-stressor transition model linking threat-context updating, cardiac vagal regulation and continuing HPA output. Distinguishes event offset, system-specific resolution and demonstrated adaptation, with testable propositions.
Scope & interpretation
A proposed framework, not a newly discovered biological system or clinically validated score. Added model parameters require identifiable measurement, independent prediction and experimental tests.
Study at a glance
- POPULATION & SAMPLE
- Structured narrative synthesis focused mainly on adult psychosocial-stress paradigms, drawing on several evidence levels.
- EXPOSURE / INTERVENTION / SUBJECT
- Post-stressor hormonal, autonomic, neural, cognitive and immune processes.
- OUTCOMES
- Mechanistic hypotheses, competing explanations and measurement recommendations.
- TIME FRAME
- Published 12 October 2026; timescales depend on the system.
Cited on this site
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
Download detailed editorial record (JSON) ↓
How responsibilities and review are recorded ↗Scope of this reading note
Publisher full-text scope, model propositions, limitations and declarations. This note does not independently validate the proposed mechanisms or reassess every cited study.
- Study funding
- Authors report no external funding; acknowledge institutional support from Henan Provincial People’s Hospital and Sichuan Academy of Medical Sciences–Sichuan Provincial People’s Hospital.
- Competing interests
- The authors declare no competing interests.
Project support
Founded and supported by Resilio.
Read the editorial standards ↗