Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change
Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH
Psychoneuroendocrinology · 2003
What the research tells us
Distinguishes area under the curve relative to ground (AUCg) from area relative to the initial value (AUCi). Overall concentration over time and change from baseline can show different associations.
Scope & interpretation
Neither summary automatically estimates recovery duration. Formula, baseline and observation window must be stated. A linked 2004 letter and reply are commentary, not automatically an erratum.
Study at a glance
- POPULATION & SAMPLE
- Methodological examples using artificial and human hormone data.
- EXPOSURE / INTERVENTION / SUBJECT
- Repeated hormone concentration measurements summarized with trapezoidal formulas.
- OUTCOMES
- AUCg and AUCi and their interpretation.
- TIME FRAME
- Depends on the time series supplied; no universal sampling interval.
Cited on this site
Editorial & review record
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
Download detailed editorial record (JSON) ↓
How responsibilities and review are recorded ↗Scope of this reading note
PubMed original abstract and bibliographic record; linked letter/reply record checked, but its text was not available for assessment. No new AUC calculations were performed.
- Funding & competing interests
- Funding and competing-interest details have not been verified against the full text. Consult the original publication’s declarations.
Project support
Founded and supported by Resilio.
Read the editorial standards ↗