TAP reading note: Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial
Structured activity reduced major mobility disability relative to health education: HR 0.82 (95% CI 0.69–0.98). This is evidence about maintaining walking ability in older adults with limitations, not a direct whole-body reserve measurement.
Updated 2026-11-13 · Archived
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What the study found
Structured activity reduced major mobility disability relative to health education: HR 0.82 (95% CI 0.69–0.98). This is evidence about maintaining walking ability in older adults with limitations, not a direct whole-body reserve measurement.
Scope & limitations
1,635 sedentary adults aged 70–89, with functional limitations but initially able to walk 400 m.
Selected volunteers and a supported programme limit generalisation. Serious adverse events occurred in 49.4% versus 45.7% (RR 1.08, 95% CI 0.98–1.20); nonsignificance does not prove equal safety.
Population & sample
1,635 sedentary adults aged 70–89, with functional limitations but initially able to walk 400 m.
Exposure or intervention
Moderate activity including walking, resistance and flexibility, versus health education and upper-limb stretching.
Outcomes
Loss of ability to walk 400 m; persistent disability and adverse events.
Time frame
Mean 2.6 years.
Research funding
NIH/NIA UO1AG22376 (as printed), NHLBI 3U01AG022376-05A2S and intramural support; Pepper Centers 1P30AG028740, 1P30AG21332, 1P30AG031679, P30AG024827, P30AG021342; CTSA UL1RR025744, U54RR025208, UL1TR000142; 1R24HD065688-01A1; K07AG3587 (as printed); VA career-development support; USDA 58-1950-0-014. NIH held one of 12 steering-committee votes.
Research conflicts of interest
Blair: BodyMedia, Coca-Cola and Technogym grants. Fielding: grants, consulting or board relationships involving Dairy Research Institute/Dairy Management, Department of Defense, Nestle, Regeneron, Unilever, Eli Lilly, Essentient, Merck, Aging in Motion, Ammonett, Cytokinetics, Myosyntax and Segterra. McDermott: Informed Medical Decisions Foundation editorship. Sink: Alzheimer’s Association and Donald W. Reynolds Foundation funding and a medical-food trial investigator role. No other disclosures were reported.
Reading scope
Original published PDF: eligibility, intervention, primary results, adverse-event table and declarations. Supplements and participant-level data were not reanalysed.
References
Publication record
TAP-RDN-0076 · v1.0 · English
Author: TAP Editorial Team ·
The Allostasis Project is founded and supported by Resilio.
Record for v1.0 · Updated
Editorial responsibility: TAP Editorial Team
Editorial note
Under the editorial responsibility of the TAP Editorial Team, this publication used AI assistance for content organization and editing.
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SHA-256: 1682128d87c6d733e19528e9b34c1d0dcb713cf029d00a788f5403dfe8f30150
Captured: 2026-11-13T04:08:26.774Z
- v1.0 · 2026-11-13