TAP reading note: The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans

What the study found

After one resistance-exercise bout, 100 g of milk protein produced a larger and more prolonged protein-synthesis response than 25 g over the 12-hour observation. This challenges a fixed 20–30 g utilization ceiling under those conditions.

Scope & limitations

36 healthy, recreationally active young men, randomized to 0, 25 or 100 g of milk protein; 12 per group.

Only three doses, one exercise bout and a 12-hour window were tested. The title’s “no upper limit” should not be read as proof of unlimited benefit, an optimal meal size or long-term safety. There was no matched-total comparison of one 100 g dose versus four 25 g meals, and no months-long growth or strength outcome.

Population & sample

36 healthy, recreationally active young men, randomized to 0, 25 or 100 g of milk protein; 12 per group.

Exposure or intervention

Double-blind parallel trial; intrinsically labelled milk protein and intravenous stable-isotope tracers after whole-body resistance exercise.

Outcomes

Amino-acid appearance and incorporation, muscle and whole-body protein synthesis, protein balance and oxidation.

Time frame

12 hours after a single exercise bout and test drink.

Research funding

No separate study funding statement was identified in the consulted main text. The declarations state that FrieslandCampina had no role in funding, data collection, analysis or manuscript preparation.

Research conflicts of interest

Glenn A.A. van Lieshout was a FrieslandCampina employee. The paper links the Maastricht University profiles of Trommelen and van Loon for their wider career funding; those histories were not fully audited here.

Reading scope

PMC main text: design, results and key figures, limitations, participant criteria and declarations. Supplementary participant-level data were not reanalysed.

• Full text in PubMed Central ↗

References

1. Jorn Trommelen et al. (2023). The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2023.101324

Publication record

TAP-RDN-0083 · v1.0 · English

Author: TAP Editorial Team ·

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